Table 2

Plasmodium falciparum Histidine-Rich Protein 2 and 3 Gene Deletions in Strains from Nigeria, Sudan, and South Sudan

Christiane Prosser

, Karryn Gresty, John Ellis, Wieland Meyer, Karen Anderson, Rogan Lee, and Qin Cheng

Author affiliations: Australian Defence Force Malaria and Infectious Disease Institute, Brisbane, Queensland, Australia (C. Prosser, K. Gresty, K. Anderson, Q. Cheng); Westmead Institute for Medical Research, Westmead, New South Wales, Australia (C. Prosser, W. Meyer); University of Sydney, Sydney, New South Wales, Australia (C. Prosser, W. Meyer, R. Lee); QIMR–Berghofer Medical Research Institute, Brisbane (K. Gresty, K. Anderson, Q. Cheng); University of Technology Sydney, Sydney (J. Ellis); Westmead Hospital, Westmead (W. Meyer); Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney (W. Meyer); Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, Westmead Hospital, Westmead (R. Lee)

Main Article

Assessment of HRP2-based SD BioLine RDT for pfhrp2/pfhrp3 deletion genotypes for Plasmodium spp. isolates, by parasite country of origin, Australia*

Country	Sample ID	Collection year	Parasitemia, % erythrocytes	Parasites/μL blood	Genotype, pfhrp2/pfhrp3	BioLine RDT†
Country	Sample ID	Collection year	Parasitemia, % erythrocytes	Parasites/μL blood	Genotype, pfhrp2/pfhrp3	Pan	Pf
Sudan	BDA1	2016	0.16	8,000	+/+	1	2
Sudan	BDA2	2016	0.79	39,500	–/+	1	3
Sudan	BDA3	2016	0.3	15,000	–/+	0	1
Sudan	BDA4	2016	0.02	1,000	–/+	0	1
Sudan	BDA37	2014	<0.01	NA	–/+	0	0
South Sudan	BDD4	2018	1.24	62,000	+/–	1†	3
South Sudan	BDC98	2018	0.5	25,000	–/+	1	1
South Sudan	BDB94	2017	0.5	25,000	–/+	1	1
South Sudan	BDB99	2017	<0.01	NA	–/+	0	1†
Nigeria	BDA24	2015	1.1	55,000	–/+	0	1
Nigeria	BDA92	2012	4	200,000	–/+	1	1
Nigeria	BDA91	2012	2.5	125,000	–/+	1	1
Nigeria	BDB31	2011	0.08	4,000	–/+	0	0
Kenya	BDA42	2014	0.12	6,000	–/+	2	1
Kenya	BDB19	2011	<0.01	NA	+/+	0	3
Ghana	BDA5	2016	<0.01	NA	–/+	1‡	1‡
Tanzania	BDA28	2015	<0.01	NA	–/+	0	1
Zambia	BDA31	2015	0.2	10,000	–/+	0	1
Togo	BDA50	2014	0.27	13,500	–/+	0	1
Peru	BDA52	2014	0.4	20,000	+/–	1	3
Papua New Guinea	BDB6	2012	2.81	140,500	+/+	1‡	2
Papua New Guinea	BDB5	2012	<0.01	NA	+/+	1‡	1
Africa	BDA99	2012	0.46	23,000	+/+	0	3
Africa	BDA90	2012	1.2	60,000	+/+	0	3
Africa	BDA100	2012	<0.01	NA	+/+	0	1
Africa	BDB11	2011	<0.01	NA	–/+	0	0
Africa	BDB46	2010	0.01	500	–/+	0	0

*Gray shading signifies a negative result with both the pan-pLDH and pfHRP2 antigen tests on the RDT. Africa indicates unknown country of origin. ID, identification; NA, not applicable; pan, pan–Plasmodium spp.; Pf, P. falciparum; pfHRP2, Plasmodium falciparum histidine-rich protein 2; pLDH, Plasmodium lactate dehydrogenase; RDT, rapid diagnostic test. †0–4 result scored by World Health Organization guidelines. ‡Sample results matched outcomes using CareStart Malaria RDT, whereas parasites were not detected by BinaxNOW RDT (Appendix Figures 2, 3).

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Page created: December 22, 2020

Page updated: January 23, 2021

Page reviewed: January 23, 2021

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