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Volume 27, Number 8—August 2021
Research

Modeling Immune Evasion and Vaccine Limitations by Targeted Nasopharyngeal Bordetella pertussis Inoculation in Mice

Illiassou Hamidou Soumana12, Bodo Linz13, Kalyan K. Dewan1Comments to Author , Demba Sarr, Monica C. Gestal4, Laura K. Howard5, Amanda D. Caulfield, Balázs Rada, and Eric T. Harvill
Author affiliation: University of Georgia, Athens, Georgia, USA

Main Article

Figure 7

Comparison of nasal cavity colonization of Bordetella pertussis among experimentally infected mice after intraperitoneal vaccination with acellular pertussis (aP) or whole-cell pertussis (wP) vaccine. Graph compares colonization profiles over 28 days. Green squares indicate naive mice; blue squares indicate mice vaccinated with aP; red squares indicate mice vaccinated wP. Error bars indicate SD of the mean for 4 biologic replicates. The study was conducted twice; results are shown for a single experiment. Dotted line indicates limit of detection. p values indicate statistically significant differences between aP- and wP-vaccinated mice.

Figure 7. Comparison of nasal cavity colonization of Bordetella pertussis among experimentally infected mice after intraperitoneal vaccination with acellular pertussis (aP) or whole-cell pertussis (wP) vaccine. Graph compares colonization profiles over 28 days. Green squares indicate naive mice; blue squares indicate mice vaccinated with aP; red squares indicate mice vaccinated wP. Error bars indicate SD of the mean for 4 biologic replicates. The study was conducted twice; results are shown for a single experiment. Dotted line indicates limit of detection. p values indicate statistically significant differences between aP- and wP-vaccinated mice.

Main Article

1These authors contributed equally to this article.

2Current affiliation: University of British Columbia, Vancouver, British Columbia, Canada.

3Current affiliation: Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany.

4Current affiliation: Louisiana State University Health Science Center, Shreveport, Louisiana, USA.

5Current affiliation: Augusta University, Augusta, Georgia, USA.

Page created: June 16, 2021
Page updated: July 18, 2021
Page reviewed: July 18, 2021
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