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Volume 28, Number 3—March 2022

Plasmodium falciparum pfhrp2 and pfhrp3 Gene Deletions from Persons with Symptomatic Malaria Infection in Ethiopia, Kenya, Madagascar, and Rwanda

Eric RogierComments to Author , Jessica N. McCaffery, Doug Nace, Samaly Souza Svigel, Ashenafi Assefa, Jimee Hwang, Simon Kariuki, Aaron M. Samuels, Nelli Westercamp, Arsène Ratsimbasoa, Milijaona Randrianarivelojosia, Aline Uwimana, Venkatachalam Udhayakumar, and Eric S. Halsey
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (E. Rogier, J.N. McCaffery, D. Nace, S.S. Svigel, A.M. Samuels, N. Westercamp, V. Udhayakumar); Ethiopia Public Health Institute, Addis Ababa, Ethiopia (A. Assefa); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (J. Hwang, E.S. Halsey); Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya (S. Kariuki); Centers for Disease Control and Prevention, Kisumu (A.M. Samuels); Madagascar National Malaria Control Program, Antananarivo, Madagascar (A. Ratsimbasoa); Institut Pasteur de Madagascar, Antananarivo (M. Randrianarivelojosia); Université de Toliara, Toliara, Madagascar (M. Randrianarivelojosia); Rwanda Biomedical Center, Kigali, Rwanda (A. Uwimana)

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Table 3

Deletion genotypes by individual therapeutic efficacy study sites, Ethiopia, Kenya, Madagascar, and Rwanda

Country and study site No. specimens at enrollment* No. (%) specimens detected with pfhrp2–/pfhrp3 No. (%) specimens detected with pfhrp2–/pfhrp3+ No. (%) specimens detected with pfhrp2+/pfhrp3
Arba Minch 15 0 0 2 (13.3)
3 (2.3)
2 (1.5)
2 (1.5)
Ankazomborona 168 0 3 (1.8) 1 (0.6)
Antsenavolo 54 0 0 0
Kianjavato 116 0 0 0
Matanga 172 0 0 0
1 (0.9)
Bugarama 88 0 0 1 (1.1)
Masaka 42 0 0 0
Rukara 88 0 0 0

*Percentages may underestimate the actual amount of deleted parasites because not all samples were genotyped, rather only those found to initially have depressed histidine-rich protein 2 levels. All samples with high histidine-rich protein 2 signal assumed to be from wild-type infections.

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Page created: January 12, 2022
Page updated: February 21, 2022
Page reviewed: February 21, 2022
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