Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 28, Number 3—March 2022
Research

Plasmodium falciparum pfhrp2 and pfhrp3 Gene Deletions from Persons with Symptomatic Malaria Infection in Ethiopia, Kenya, Madagascar, and Rwanda

Eric RogierComments to Author , Jessica N. McCaffery, Doug Nace, Samaly Souza Svigel, Ashenafi Assefa, Jimee Hwang, Simon Kariuki, Aaron M. Samuels, Nelli Westercamp, Arsène Ratsimbasoa, Milijaona Randrianarivelojosia, Aline Uwimana, Venkatachalam Udhayakumar, and Eric S. Halsey
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (E. Rogier, J.N. McCaffery, D. Nace, S.S. Svigel, A.M. Samuels, N. Westercamp, V. Udhayakumar); Ethiopia Public Health Institute, Addis Ababa, Ethiopia (A. Assefa); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (J. Hwang, E.S. Halsey); Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya (S. Kariuki); Centers for Disease Control and Prevention, Kisumu (A.M. Samuels); Madagascar National Malaria Control Program, Antananarivo, Madagascar (A. Ratsimbasoa); Institut Pasteur de Madagascar, Antananarivo (M. Randrianarivelojosia); Université de Toliara, Toliara, Madagascar (M. Randrianarivelojosia); Rwanda Biomedical Center, Kigali, Rwanda (A. Uwimana)

Main Article

Table 3

Deletion genotypes by individual therapeutic efficacy study sites, Ethiopia, Kenya, Madagascar, and Rwanda

Country and study site No. specimens at enrollment* No. (%) specimens detected with pfhrp2–/pfhrp3– No. (%) specimens detected with pfhrp2–/pfhrp3+ No. (%) specimens detected with pfhrp2+/pfhrp3–
Ethiopia
Arba Minch 15 0 0 2 (13.3)
Pawe
 132
 3 (2.3)
 2 (1.5)
 2 (1.5)
Kenya
Siaya
 332
 0
 0
 0
Madagascar
Ankazomborona 168 0 3 (1.8) 1 (0.6)
Antsenavolo 54 0 0 0
Kianjavato 116 0 0 0
Matanga 172 0 0 0
Vohitromby
 110
 0
 1 (0.9)
 0
Rwanda
Bugarama 88 0 0 1 (1.1)
Masaka 42 0 0 0
Rukara 88 0 0 0

*Percentages may underestimate the actual amount of deleted parasites because not all samples were genotyped, rather only those found to initially have depressed histidine-rich protein 2 levels. All samples with high histidine-rich protein 2 signal assumed to be from wild-type infections.

Main Article

Page created: January 12, 2022
Page updated: February 21, 2022
Page reviewed: February 21, 2022
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external