Volume 28, Number 9—September 2022
Research
Fulminant Transfusion-Associated Hepatitis E Virus Infection Despite Screening, England, 2016–2020
Heli Harvala
, Claire Reynolds, Su Brailsford, and Katy Davison
, Claire Reynolds, Su Brailsford, and Katy Davison
Table 5
Details of lookback investigations into 9 HEV RNA positive platelet donations supplied for clinical use in England, March 2016 to December 2020*
| Donation no. | HEV viral load, IU/mL† | Components | Recipient details | Recipient follow-up testing results |
|---|---|---|---|---|
| Donation 1 |
4 |
Platelet 1 | Hospitals informed, no data back |
NA |
| Platelet 2 |
||||
| Donation 2 |
8 |
Platelet 1 | Hospitals informed, no data back |
NA |
| Platelet 2 |
||||
| Donation 3 |
<37 |
Platelet 1 | Hospitals informed, no data back |
NA |
| Platelet 2 |
||||
| Donation 4 |
<37 |
Platelet 1 | Hospitals responded, no evidence of transmission |
NA |
| Platelet 2 |
||||
| Donation 5 |
37 |
Platelet 1 | M, 50–60 years, B-cell lymphoma | Confirmed transmission |
| Platelet 2 |
F, 20-30 y, sepsis |
Deceased |
||
| Donation 6 |
37 |
Platelet 1 | F, 60–70 y, aplastic anemia | Tested negative |
| Platelet 2 |
M, 50–60 y, lymphoma |
Tested negative |
||
| Donation 7 |
4.5 |
Platelet 1 | M, 40–50 y, aplastic anemia | Confirmed transmission |
| Platelet 2 |
F, 50–60 y, vascular syndrome |
Tested negative |
||
| Donation 8 |
10 |
Platelet 1 | M, 60–70 y, aplastic anemia | Tested negative |
| Platelet 2 |
M, <10 y, cancer |
Deceased |
||
| Donation 9 | 3 | Platelet 1 | F, 40–50 y, myelodysplastic syndrome | Tested negative |
| Platelet 2 | M, 40–50 y, acute myeloid leukemia | Deceased |
*Each donation was tested for HEV RNA and divided into 2 platelet packs. †Estimated viral loads given where available. HEV, hepatitis E virus; NA, not applicable.
Page created: July 14, 2022
Page updated: August 19, 2022
Page reviewed: August 19, 2022
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