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Volume 29, Number 1—January 2023
Research

Human Immunity and Susceptibility to Influenza A(H3) Viruses of Avian, Equine, and Swine Origin

Elien Vandoorn, Wojciech Stadejek, Isabel Leroux-Roels, Geert Leroux-Roels, Anna Parys, and Kristien Van ReethComments to Author 
Author affiliations: Ghent University, Merelbeke, Belgium (E. Vandoorn, W. Stadejek, A. Parys, K. Van Reeth); Ghent University and Ghent University Hospital, Ghent, Belgium (I. Leroux-Roels, G. Leroux-Roels)

Main Article

Table 5

Geometric mean of virus neutralization antibody titers against H3 influenza A viruses of different species in different age groups of the human population, 2017–2018, Belgium*

Birth year range
(age, y)†
No. Avian
Equine
Human
Swine
dkUK63
mlOH18
mlBE18
chG19
eqCH18
HK68‡
swG17
swIN16
swMO15
Eurasian Am. Eurasian Eurasian FC1 Pandemic European N. Am. N. Am.
1921–1926 (96–91) 14 7 (5–9) 10 (7–15) 8 (6–12) 6 (5–7) 7 (5–10) 30 (12–72) 10 (5–19) 104 (44–247) 116 (38–351)
1927–1936 (90–81) 30 6 (5–7) 12 (9–18) 12 (8–17) 6 (5–7) 7 (5–8) 43 (27–68) 9 (6–11) 60 (34–106) 105 (62–176)
1937–1946 (80–71) 30 5 (5–6) 9 (7–12) 10 (7–14) 5 (5–6) 6 (5–6) 48 (32–72) 9 (6–12) 33 (21–53) 79 (46–137)
1947–1956 (70–61) 30 7 (5–9) 14 (10–21) 15 (11–22) 6 (5–7) 7 (5–9) 69 (44–110) 8 (6–11) 31 (18–52) 35 (20–60)
1957–1966 (60–51) 30 6 (5–7) 15 (11–20) 19 (13–27) 7 (5–9) 6 (5–6) 100 (72–138) 12 (8–16) 28 (17–47) 37 (24–56)
1967–1976 (50–41) 30 7 (5–9) 11 (8–17) 12 (8–17) 6 (5–7) 6 (5–7) 31 (17–55) 18 (13–25) 94 (56–157) 60 (35–103)
1977–1986 (40–31) 30 6 (5–7) 7 (6–8) 6 (5–7) 5 (5–6) 8 (6–10) 9 (6–13) 9 (7–12) 285 (175–462) 84 (45–154)
1987–1996 (30–21) 30 5 (5–5) 6 (5–6) 5 (5–6) 5 (5–5) 6 (5–7) 6 (5–6) 7 (6–8) 219 (129–372) 225 (156–323)
1997–2006 (20–11) 30 5 (5–5) 5 (5–5) 5 (5–5) 5 (5–5) 5 (5–6) 5 (5–6) 6 (5–7) 18 (11–29) 163 (96–275)
2007–2017 (10–0)
32
5 (5–5)
5 (5–5)
5 (5–5)
5 (5–5)

6 (5–7)

6 (5–7)

6 (5–6)
8 (6–10)
40 (24–67)
1921–2017 (96–0) 286 6 (5–6) 9 (8–10) 9 (8–10) 6 (5–6) 6 (6–7) 21 (18–25) 9 (8–9) 49 (40–60) 77 (64–91)

*Values represent geometric mean virus neutralization titers (95% CI). Viruses are ordered according to host species and chronologically according to the emergence of each of the influenza A virus lineages in these species. Complete isolate names are provided in [[ANCHOR###T2###Table 2###Anchor]]. Am., American; FC1, Florida clade 1; N. Am., North American. †Age at the end of 2017. ‡Human influenza A virus that no longer circulates.

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Page updated: December 21, 2022
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