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Volume 29, Number 12—December 2023
Research

Fatal Human Neurologic Infection Caused by Pigeon Avian Paramyxovirus-1, Australia

Siobhan Hurley1Comments to Author , John Sebastian Eden1, John Bingham, Michael Rodriguez, Matthew J. Neave, Alexandra Johnson, Annaleise R. Howard-Jones, Jen Kok, Antoinette Anazodo, Brendan McMullan, David T. Williams, James Watson, Annalisa Solinas, Ki Wook Kim2, and William Rawlinson2
Author affiliations: Prince of Wales Hospital, Randwick, New South Wales, Australia (S. Hurley, K.W. Kim); Westmead Institute for Medical Research Centre for Virus Research, Westmead, New South Wales, Australia (J.S. Eden); Sydney Institute for Infectious Diseases, University of Sydney Faculty of Medicine and Health, Sydney, New South Wales, Australia (J.S. Eden, A.R. Howard-Jones); CSIRO Australian Centre for Disease Preparedness, Geelong, Victoria, Australia (J. Bingham, M.J. Neave, D.T. Williams, J. Watson); Prince of Wales and Sydney Children’s Hospital, Randwick (M. Rodriguez, A. Solinas); Sydney Children’s Hospital, Randwick (A. Johnson, B. McMullan); Centre for Infectious Diseases and Microbiology Laboratory Services, New South Wales Health Pathology–Institute of Clinical Pathology and Medical Research, Westmead (A.R. Howard-Jones, J. Kok); Kids Cancer Centre, Sydney Children’s Hospital, Randwick (A. Anazodo); University of New South Wales Faculty of Medicine and Health, School of Clinical Medicine, Sydney (B. McMullan, K. Kim); Prince of Wales Hospital and Community Health Services, Sydney (W. Rawlinson); University of New South Wales Schools of Clinical Medicine, Biotechnology and Biomolecular Sciences, Sydney (W. Rawlinson)

Main Article

Figure 1

Histology of brain tissue and imaging from a fatal neurologic infection in an immunocompromised child in Australia that was caused by APMV-1. A) Brain biopsy showing extensive cortical necrosis with a dense infiltrate of macrophages. Hematoxylin and eosin stain; original magnification ×20. B) Immunohistochemistry of brain biopsy showing cytoplasmic APMV-1 nucleoprotein, probably in neurons, with axon-like processes (arrowheads). Original magnification ×20 (inset ×40). C) Immunohistochemistry of APMV-1 nucleoprotein, demonstrating the absence of immunolabeling in normal brain tissue. APMV, avian paramyxovirus.

Figure 1. Histology of brain tissue and imaging from a fatal neurologic infection in an immunocompromised child in Australia that was caused by APMV-1. A) Brain biopsy showing extensive cortical necrosis with a dense infiltrate of macrophages. Hematoxylin and eosin stain; original magnification ×20. B) Immunohistochemistry of brain biopsy showing cytoplasmic APMV-1 nucleoprotein, probably in neurons, with axon-like processes (arrowheads). Original magnification ×20 (inset ×40). C) Immunohistochemistry of APMV-1 nucleoprotein, demonstrating the absence of immunolabeling in normal brain tissue. APMV, avian paramyxovirus.

Main Article

1These first authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: November 13, 2023
Page updated: November 18, 2023
Page reviewed: November 18, 2023
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