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Volume 29, Number 12—December 2023
Research

Fatal Human Neurologic Infection Caused by Pigeon Avian Paramyxovirus-1, Australia

Siobhan Hurley1Comments to Author , John Sebastian Eden1, John Bingham, Michael Rodriguez, Matthew J. Neave, Alexandra Johnson, Annaleise R. Howard-Jones, Jen Kok, Antoinette Anazodo, Brendan McMullan, David T. Williams, James Watson, Annalisa Solinas, Ki Wook Kim2, and William Rawlinson2
Author affiliations: Prince of Wales Hospital, Randwick, New South Wales, Australia (S. Hurley, K.W. Kim); Westmead Institute for Medical Research Centre for Virus Research, Westmead, New South Wales, Australia (J.S. Eden); Sydney Institute for Infectious Diseases, University of Sydney Faculty of Medicine and Health, Sydney, New South Wales, Australia (J.S. Eden, A.R. Howard-Jones); CSIRO Australian Centre for Disease Preparedness, Geelong, Victoria, Australia (J. Bingham, M.J. Neave, D.T. Williams, J. Watson); Prince of Wales and Sydney Children’s Hospital, Randwick (M. Rodriguez, A. Solinas); Sydney Children’s Hospital, Randwick (A. Johnson, B. McMullan); Centre for Infectious Diseases and Microbiology Laboratory Services, New South Wales Health Pathology–Institute of Clinical Pathology and Medical Research, Westmead (A.R. Howard-Jones, J. Kok); Kids Cancer Centre, Sydney Children’s Hospital, Randwick (A. Anazodo); University of New South Wales Faculty of Medicine and Health, School of Clinical Medicine, Sydney (B. McMullan, K. Kim); Prince of Wales Hospital and Community Health Services, Sydney (W. Rawlinson); University of New South Wales Schools of Clinical Medicine, Biotechnology and Biomolecular Sciences, Sydney (W. Rawlinson)

Main Article

Figure 5

Phylogeny of avian paramyxovirus type 1 strain from an immunocompromised child in Australia (bold). Tree was prepared from MAFFT-aligned fusion gene sequences of genotype VI sublineage 2.1.1.2.2 strains (classified as pigeon avian paramyxovirus 1) using PhyML with the Hasegawa-Kishino-Yano + gamma DNA substitution model and rooted with a genotype VI sublineage 2.1.1.2.1 outgroup (HM063425/Pigeon/CHN/P4). Red dot indicates virus from this case; GenBank accession numbers are provided for reference sequences. Gray box indicates the branch containing the virus we identified, expanded to show detail. Colored circles at tips indicate country of sampling. The virus from our study appears to be related to viruses circulating in Australia since at least 2011. Node support values show Shimodaira-Hasegawa—like approximate likelihood ratio test statistics; branch lengths are proportional to the scale of the number of substitutions per site. Scale bars indicate number of substitutions per site. All strains used in this analysis are listed in the Appendix.

Figure 5. Phylogeny of avian paramyxovirus type 1 strain from an immunocompromised child in Australia (bold). Tree was prepared from MAFFT-aligned fusion gene sequences of genotype VI sublineage 2.1.1.2.2 strains (classified as pigeon avian paramyxovirus 1) using PhyML with the Hasegawa-Kishino-Yano + gamma DNA substitution model and rooted with a genotype VI sublineage 2.1.1.2.1 outgroup (HM063425/Pigeon/CHN/P4). Red dot indicates virus from this case; GenBank accession numbers are provided for reference sequences. Gray box indicates the branch containing the virus we identified, expanded to show detail. Colored circles at tips indicate country of sampling. The virus from our study appears to be related to viruses circulating in Australia since at least 2011. Node support values show Shimodaira-Hasegawa—like approximate likelihood ratio test statistics; branch lengths are proportional to the scale of the number of substitutions per site. Scale bars indicate number of substitutions per site. All strains used in this analysis are listed in the Appendix.

Main Article

1These first authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: November 13, 2023
Page updated: November 18, 2023
Page reviewed: November 18, 2023
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