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Volume 29, Number 7—July 2023
Research

Highly Pathogenic Avian Influenza Virus (H5N1) Clade 2.3.4.4b Introduced by Wild Birds, China, 2021

Jingman Tian1, Xiaoli Bai1, Minghui Li1, Xianying Zeng1, Jia Xu, Peng Li, Miao Wang, Xingdong Song, Zhiguo Zhao, Guobin Tian, Liling Liu, Yuntao Guan, Yanbing LiComments to Author , and Hualan ChenComments to Author 
Author affiliations: State Key Laboratory for Animal Didease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China (J. Tian, X. Bai, M. Li, X. Zeng, X. Song, Z. Zhao, G. Tian, L. Liu, Y. Guan, Y Li, H. Chen); Preventive and Control Center for Animal Disease of Heilongjiang Province, Harbin (J. Xu, P. Li, M. Wang)

Main Article

Figure 2

Replication and virulence of representative highly pathogenic avian influenza virus (H5N1) viruses in mice and ducks. A) Virus titers in organs of mice that were humanely killed on postinfection day 3 with 106 EID50 of the test viruses. B, C) MLD50 of the indicated viruses. D) Virus titers in organs of ducks that were killed on day 3 post inoculation with 106 EID50 in 0.1 mL of the indicated viruses. E) Virus shedding from ducks on the indicated days after inoculation. F) Death pattern of ducks in the infected and control groups. EID50, 50% egg infectious dose; MLD50, 50% lethal dose for mice.

Figure 2. Replication and virulence of representative highly pathogenic avian influenza virus (H5N1) viruses in mice and ducks. A) Virus titers in organs of mice that were humanely killed on postinfection day 3 with 106 EID50 of the test viruses. B, C) MLD50 of the indicated viruses. D) Virus titers in organs of ducks that were killed on day 3 post inoculation with 106 EID50 in 0.1 mL of the indicated viruses. E) Virus shedding from ducks on the indicated days after inoculation. F) Death pattern of ducks in the infected and control groups. EID50, 50% egg infectious dose; MLD50, 50% lethal dose for mice.

Main Article

1These authors contributed equally to this article.

Page created: May 21, 2023
Page updated: June 20, 2023
Page reviewed: June 20, 2023
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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