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Volume 29, Number 7—July 2023
Research

Highly Pathogenic Avian Influenza Virus (H5N1) Clade 2.3.4.4b Introduced by Wild Birds, China, 2021

Jingman Tian1, Xiaoli Bai1, Minghui Li1, Xianying Zeng1, Jia Xu, Peng Li, Miao Wang, Xingdong Song, Zhiguo Zhao, Guobin Tian, Liling Liu, Yuntao Guan, Yanbing LiComments to Author , and Hualan ChenComments to Author 
Author affiliations: State Key Laboratory for Animal Didease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China (J. Tian, X. Bai, M. Li, X. Zeng, X. Song, Z. Zhao, G. Tian, L. Liu, Y. Guan, Y Li, H. Chen); Preventive and Control Center for Animal Disease of Heilongjiang Province, Harbin (J. Xu, P. Li, M. Wang)

Main Article

Figure 3

Antigenic difference of avian influenza (H5N1) virus isolates with H5 vaccine strains and protective efficacy of H5 vaccine against the challenge of H5N1 virus. A) Antigenic cartography of H5N1 viruses. The map was generated by using Antigenic Cartography software (https://acmacs-web.antigenic-cartography.org); 1 unit (grid) represents a 2-fold change in the HI assay results (Appendix 2 Table 7). B) HI antibody titers of vaccinated chickens against the vaccine seed virus and the challenge strain. C) Virus shedding from chickens on postchallenge days 3 and 5. D) Survival patterns of chickens in the vaccinated and control groups after challenge with the indicated H5N1 virus. EID50, 50% egg infectious dose; HI, hemagglutination inhibition.

Figure 3. Antigenic difference of avian influenza (H5N1) virus isolates with H5 vaccine strains and protective efficacy of H5 vaccine against the challenge of H5N1 virus. A) Antigenic cartography of H5N1 viruses. The map was generated by using Antigenic Cartography software (https://acmacs-web.antigenic-cartography.org); 1 unit (grid) represents a 2-fold change in the HI assay results (Appendix 2 Table 7). B) HI antibody titers of vaccinated chickens against the vaccine seed virus and the challenge strain. C) Virus shedding from chickens on postchallenge days 3 and 5. D) Survival patterns of chickens in the vaccinated and control groups after challenge with the indicated H5N1 virus. EID50, 50% egg infectious dose; HI, hemagglutination inhibition.

Main Article

1These authors contributed equally to this article.

Page created: May 21, 2023
Page updated: June 20, 2023
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