, J.W.M. Lee*, M.L.N. Leong*, A.-E. Ling†, H.-C. Tan‡, and E.E. Ooi‡
Figure 4. Atomic force microscopy of Vero cells infected with severe acute respiratory syndrome–associated coronavirus at 15 h after infection. A) At much higher resolution imaging of the edge of a cell, a virus particle (thick arrow) in the process of extruding from the cell plasma membrane (PM) after fusion of the transport vesicle with the cell membrane. PM shows some loss of integrity (thin arrows) during this exit process. B) A three-dimensional reconstruction of the extruding virus particle from panel B. Arrow indicates the thickened cell edge.