Acquisition of Plasmid with Carbapenem-Resistance Gene blaKPC2 in Hypervirulent Klebsiella pneumoniae, Singapore
Yahua Chen, Kalisvar Marimuthu, Jeanette Teo, Indumathi Venkatachalam, Benjamin Pei Zhi Cherng, Liang De Wang, Sai Rama Sridatta Prakki, Weizhen Xu, Yi Han Tan, Lan Chi Nguyen, Tse Hsien Koh, Oon Tek Ng, and Yunn-Hwen Gan
Author affiliations: National University of Singapore, Singapore (Y. Chen, Y.H. Tan, L.C. Nguyen, Y.-H. Gan); National Centre for Infectious Diseases, Singapore (K. Marimuthu, L.D. Wang, S.R.S. Prakki, W. Xu, O.T. Ng); Tan Tock Seng Hospital, Singapore (K. Marimuthu, O.T. Ng); National University Hospital, Singapore (J. Teo); Singapore General Hospital, Singapore (I. Venkatachalam, B.P.Z. Cherng, T.H. Koh); Nanyang Technological University, Singapore (O.T. Ng)
Figure 5. Conjugation ability of pKPC2 from carbapenem-resistant hypervirulent Klebsiella pneumoniae isolates, Singapore, 2013–2014, to Escherichia coli SLC568. Filter matings were performed for 4 h. The conjugation frequency is the number of CFUs of transconjugants divided by the number of CFUs of recipients. Each symbol represents the value for an individual clone (n = 10) from 3 independent experiments. Horizontal bars indicate means and error bars SD. KPC, Klebsiella pneumoniae carbapenemase. ****p<0.0001.
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