Table 5

Influence of Host Genetics on the Severity of Coccidioidomycosis

Leslie Louie*

, Susanna Ng*, Rana Hajjeh†, Royce Johnson‡, Duc Vugia§, S. Benson Werner§, Ronald Talbot¶, and William Klitz*

Author affiliations: *University of California, Berkeley, California, USA; †Centers for Disease Control and Prevention, Atlanta, Georgia, USA; ‡Kern Medical Center, Bakersfield, California, USA; §California Department of Health Services, Berkeley, California, USA; ¶Kern County Public Health Department, Bakersfield, California, USA

Main Article

HLA alleles and haplotypes associated with severity of coccidioidomycosis, by ethnicity

	Caucasian			Hispanic			African-American
Locus	S v. M^a	S v. C	M v. C	S v. M	S v. C	M v. C	S v. C
a. Alleles associated with decreased risk
DQB1	*0402^b	*0604^b	*0604^b		*0302^b
	*0504^b
DRB1			*0301^c		*0407^c		*1501^c
			*1104^b		*0408^b
DRB1-DQB1	0700-0303^b	0301-0201^b	0301-0201^b		0407-0302^c	0301-0201^c	1501-0602^c
		0404-0302^b	1104-0301^b		0700-0201^b	1402-0301^c
		0700-0303^b			1101-0301^c
		1302-0604^b			0101-0501^b
DPB1						*0501^b
b. Alleles associated with increased risk
DQB1	*0602^b	rare^b	*0504^d		*0602^c
			rare^d		*0603^b
DRB1			*0303^c		*1103^c		*1301^c
			*1301^b		*1301^c		*1503^c
			rare^d		*1406^c		rare^c
					rare^b
DRB1-DQB1	1301-0602^b	1301-0602^d	1301-0504^c		0700-0301^c	rare^c	1301-0501^c
		0700-0201^b	1302-0201^c		1301-0603^b		1503-0602^c
		rare^d	0303-0201^c		1302-0301^c
			rare^b		1406-0301^c
					rare^b
DPB1				*0101^b		rare^b
				*0201^b

^{aS, severe cases; M, mild cases; C, outside controls}
^b p < 0.05
^c p < 0.01
^dp < 0.001

Main Article

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Page updated: December 15, 2010

Page reviewed: December 15, 2010

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Volume 5, Number 5—October 1999

Research

Influence of Host Genetics on the Severity of Coccidioidomycosis

Table 5