Volume 5, Number 5—October 1999
Research
Influence of Host Genetics on the Severity of Coccidioidomycosis
Table 5
HLA alleles and haplotypes associated with severity of coccidioidomycosis, by ethnicity
Caucasian |
Hispanic |
African-American |
|||||
---|---|---|---|---|---|---|---|
Locus | S v. Ma | S v. C | M v. C | S v. M | S v. C | M v. C | S v. C |
a. Alleles associated with decreased risk | |||||||
DQB1 | *0402b | *0604b | *0604b | *0302b | |||
*0504b | |||||||
DRB1 | *0301c | *0407c | *1501c | ||||
*1104b | *0408b | ||||||
DRB1-DQB1 | *0700-*0303b | *0301-*0201b | *0301-*0201b | *0407-*0302c | *0301-*0201c | *1501-*0602c | |
*0404-*0302b | *1104-*0301b | *0700-*0201b | *1402-*0301c | ||||
*0700-*0303b | *1101-*0301c | ||||||
*1302-*0604b | *0101-*0501b | ||||||
DPB1 | *0501b | ||||||
b. Alleles associated with increased risk | |||||||
DQB1 | *0602b | rareb | *0504d | *0602c | |||
rared | *0603b | ||||||
DRB1 | *0303c | *1103c | *1301c | ||||
*1301b | *1301c | *1503c | |||||
rared | *1406c | rarec | |||||
rareb | |||||||
DRB1-DQB1 | *1301-*0602b | *1301-*0602d | *1301-*0504c | *0700-*0301c | rarec | *1301-*0501c | |
*0700-*0201b | *1302-*0201c | *1301-*0603b | *1503-*0602c | ||||
rared | *0303-*0201c | *1302-*0301c | |||||
rareb | *1406-*0301c | ||||||
rareb | |||||||
DPB1 | *0101b | rareb | |||||
*0201b |
aS, severe cases; M, mild cases; C, outside controls
b p < 0.05
c p < 0.01
dp < 0.001