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Volume 5, Number 5—October 1999

Influence of Host Genetics on the Severity of Coccidioidomycosis

Leslie Louie*Comments to Author , Susanna Ng*, Rana Hajjeh†, Royce Johnson‡, Duc Vugia§, S. Benson Werner§, Ronald Talbot¶, and William Klitz*
Author affiliations: *University of California, Berkeley, California, USA; †Centers for Disease Control and Prevention, Atlanta, Georgia, USA; ‡Kern Medical Center, Bakersfield, California, USA; §California Department of Health Services, Berkeley, California, USA; ¶Kern County Public Health Department, Bakersfield, California, USA

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Table 5

HLA alleles and haplotypes associated with severity of coccidioidomycosis, by ethnicity

Locus S v. Ma S v. C M v. C S v. M S v. C M v. C S v. C
a. Alleles associated with decreased risk
DQB1 *0402b *0604b *0604b *0302b
DRB1 *0301c *0407c *1501c
*1104b *0408b
DRB1-DQB1 *0700-*0303b *0301-*0201b *0301-*0201b *0407-*0302c *0301-*0201c *1501-*0602c
*0404-*0302b *1104-*0301b *0700-*0201b *1402-*0301c
*0700-*0303b *1101-*0301c
*1302-*0604b *0101-*0501b
DPB1 *0501b
b. Alleles associated with increased risk
DQB1 *0602b rareb *0504d *0602c
rared *0603b
DRB1 *0303c *1103c *1301c
*1301b *1301c *1503c
rared *1406c rarec
DRB1-DQB1 *1301-*0602b *1301-*0602d *1301-*0504c *0700-*0301c rarec *1301-*0501c
*0700-*0201b *1302-*0201c *1301-*0603b *1503-*0602c
rared *0303-*0201c *1302-*0301c
rareb *1406-*0301c
DPB1 *0101b rareb

aS, severe cases; M, mild cases; C, outside controls
b p < 0.05
c p < 0.01
dp < 0.001

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